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Here is how to watch all Major League Soccer matches live in Week 10 on TV or streaming. You can follow along with our live scores and stats throughout the weekend as well.
Friday, May 4
| TIME (EST) | TEAM | TV | Live stream |
| 8 p.m. | Toronto v Philadelphia | PHI: PHI17; CAN: TSN 1/3/4/5 | ESPN+, Direct Kick |
Saturday, May 5
| TIME(EST) | TEAM | TV | Live stream |
| 1 p.m. | Montreal Impact v New England | ATL: Fox Sports South; CAN: TVAS | ESPN+, Direct Kick |
| 1:55 p.m. | New York Red Bulls v NYCFC | ESPN, ESPN Deportes | WatchESPN, MLS LIVE on DAZN |
| 2 p.m. | Minnesota v Vancouver | MIN: Fox Sports North; CAN: TSN1, CTV | ESPN+, Direct Kick |
| 3:55 p.m. | LAFC v FC Dallas | Univision, Univision Deportes Network, Twitter (ENG audio) | MLS LIVE on DAZN |
| 4 p.m. | Seattle v Columbus | SEA: JOEtv, YouTube TV [Seattle only]; CLB: CW Columbus, Spectrum Sports OH, BCSN2 | ESPN+, Direct Kick, MLS LIVE on DAZN |
| 8:30 p.m. | Chicago v Atlanta | ATL: Fox Sports South; CAN: TSN 1/3/4/5 | ESPN+, Direct Kick |
| 8:30 p.m. | Houston v LA Galaxy | HOU: KUBE 57; LA: Spectrum SportsNet | ESPN+, Direct Kick, MLS LIVE on DAZN |
| 8:30 p.m. | Sporting KC v Colorado | SKC: FOX Sports KC, FOX Sports Midwest Plus; COL: Altitude | ESPN+, Direct Kick, MLS LIVE on DAZN |
| 10:30 p.m. | San Jose v Portland | SJ: NBC Sports Bay Area; POR: KPDX (PDX TV) | ESPN+, Direct Kick, MLS LIVE on DAZN |
Sunday, May 6
| TIME (EST) | TEAM | TV | Live stream |
| 5 p.m. | Orlando City v Real Salt Lake | ORL: TV27; RSL: KMYU | ESPN+, Direct Kick, MLS LIVE on DAZN |