Major League Soccer teams begin U.S. Open Cup play this week in Round 4 of the tournament. Watch all three Tuesday night matches and 13 Wednesday night games right here on ProSoccerUSA.com. See the full fourth-round schedule below.
U.S. Open Cup 4th Round Schedule
| Date | Game (home team listed first) | Time | Venue |
| June 5 | Philadelphia Union (MLS) vs. Richmond Kickers (USL) | 7 p.m. ET | Talen Energy Stadium; Chester, Pa. |
| June 5 | D.C. United (MLS) vs. North Carolina FC (USL) | 7 p.m. ET | Maryland SoccerPlex; Boyds, Md. |
| June 5 | Louisville City FC (USL) vs. New England Revolution (MLS) | 7 p.m. ET | Lynn Stadium (Univ. of Louisville); Louisville, Ky. |
| June 6 | Columbus Crew SC (MLS) vs. Chicago Fire (MLS) | 7 p.m. ET | MAPFRE Stadium; Columbus, Ohio |
| June 6 | New York Red Bulls (MLS) vs. New York City FC (MLS) | 7:30 p.m. ET | Red Bull Arena; Harrison, N.J. |
| June 6 | Miami United FC (NPSL) vs. Orlando City SC (MLS) | 7:30 p.m. ET | Ted Hendricks Stadium; Hialeah, Fla. |
| June 6 | Atlanta United FC (MLS) vs. Charleston Battery (USL) | 7:30 p.m. ET | Fifth Third Bank Stadium (Kennesaw State Univ.); Kennesaw, Ga. |
| June 6 | FC Cincinnati (USL) vs. Minnesota United FC (MLS) | 7:30 p.m. ET | Nippert Stadium (Univ. of Cincinnati); Cincinnati, Ohio |
| June 6 | Nashville SC (USL) vs. Colorado Rapids (MLS) | 7:30 p.m. CT | Vanderbilt Stadium; Nashville, Tenn. |
| June 6 | Houston Dynamo (MLS) vs. NTX Rayados (Texas) | 7:30 p.m. CT | BBVA Compass Stadium; Houston, Texas |
| June 6 | San Antonio FC (USL) vs. FC Dallas (MLS) | 7:30 p.m. CT | Toyota Field; San Antonio, Texas |
| June 6 | Real Salt Lake (MLS) vs. Sporting Kansas City (MLS) | 8 p.m. MT | Rio Tinto Stadium; Sandy, Utah |
| June 6 | Los Angeles FC (MLS) vs. Fresno FC (USL) | 7 p.m. PT | Banc of California Stadium; Los Angeles, Calif. |
| June 6 | LA Galaxy (MLS) vs. FC Golden State Force (PDL) | 7:30 p.m. PT | StubHub Center Track & Field Staduim; Carson, Calif. |
| June 6 | Portland Timbers (MLS) vs. San Jose Earthquakes (MLS) | 7:30 p.m. PT | Providence Park; Portland, Ore. |
| June 6 | Sacramento Republic FC (USL) vs. Seattle Sounders FC (MLS) | 8 p.m. PT | Papa Murphy’s Park; Sacramento, Calif. |