Here is how to watch all Major League Soccer matches live in Week 22 on TV or streaming. You can follow along with our live scores and stats throughout the weekend as well.
Wednesday, July 25
| TIME(EST) | TEAM | TV | Live stream |
| 8 p.m. | DC United v NY Red Bulls | DC: NewsChannel8; RBNY: MSG | ESPN+, Direct Kick, MLS LIVE on DAZN |
| 9 p.m. | Houston v Philadelphia | HOU: KUBE 57; PHI: Live Well Network | ESPN+, Direct Kick, MLS LIVE on DAZN |
| 10:30 p.m. | San Jose v Seattle | SJ: NBC Sports Bay Area; SEA: JOEtv, YouTube TV [Seattle region only] | ESPN+, Direct Kick, MLS LIVE on DAZN |
Thursday, July 26
| TIME(EST) | TEAM | TV | Live stream |
| 8 p.m. | Orlando City v NYCFC | USA: ESPN, ESPN Deportes; CAN: TSN2 | WatchESPN |
| 10:30 p.m. | LAFC v LA Galaxy | USA: ESPN, ESPN Deportes; CAN: TSN2 | WatchESPN |
Saturday, July 28
| TIME(EST) | TEAM | TV | Live stream |
| 7 p.m. | Montreal v Atlanta | ATL: FOX Sports South; CAN: TVAS | ESPN+, Direct Kick |
| 7 p.m. | NY Red Bulls v Columbus | RBNY: MSG; CLB: CW Columbus, Spectrum Sports OH, BCSN2 | ESPN+, Direct Kick, MLS LIVE on DAZN |
| 7 p.m. | Toronto v Chicago | CHI:ESPN+; CAN: TSN4 | ESPN+, Direct Kick |
| 8 p.m. | DC United v Colorado | DC: NewsChannel8; COL: Altitude | ESPN+, Direct Kick, MLS LIVE on DAZN |
| 9 p.m. | Sporting KC v FC Dallas | USA: ESPN, ESPN Deportes | WatchESPN; CAN: MLS LIVE on DAZN |
| 10 p.m. | Vancouver v Minnesota | MIN: FOX Sports North Plus; CAN: TSN2 | ESPN+, Direct Kick |
| 10:30 p.m. | San Jose v Real Salt Lake | SJ: NBC Sports California Plus; RSL: KMYU | ESPN+, Direct Kick, MLS LIVE on DAZN |
| 11 p.m. | Portland v Houston | POR: FOX 12 Plus; HOU: KUBE 57 | ESPN+, Direct Kick, MLS LIVE on DAZN |
Sunday, July 29
| TIME(EST) | TEAM | TV | Live stream |
| 5 p.m. | Seattle v NYCFC | USA: ESPN, ESPN Deportes; CAN: TSN2 | WatchESPN |
| 9:30 p.m. | LA Galaxy v Orlando City | USA: FS1, FOX Deportes; CAN: TSN2 | FOX Sports GO |